03/24/2006

GPCR-Gq Screening Applications

Upon activation, GPCRs carry information within the cell via two major signaling pathways: one results in variations of the cyclic AMP (cAMP) level whereas the other one results in the production of inositol phosphates. Cisbios IP-One assay, based on its proprietary HTRF technology, is the first HTS system that can easily detect inositol(1)phosphate (IP1), which tightly correlates with Gq-coupled receptor activity. With IP-One and cAMP, Cisbio offers a reliable and functional platform for investigating and screening GPCR activity.







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