08/08/2005

New Amberchrom HPR10 Reversed Phase Chromatography Resin the best choice for your final polishing

Rohm and Haas Advanced Biosciences provides cost-effective products for production and purification of biopharmaceuticals. Its new Amberchrom HPR10 reversed phase chromatographic resin, a unique 10 µ monosized polymeric media, is today the best choice for your final polishing. It improves the yield and purity of final polishing operations while enabling full system CIP sanitization.

Amberchrom HPR10 is hailed by the customers as the first polymeric that performs as well as or better than premium silica in terms of yield and purity. Seamlessly scalable to production columns it provides long term stability and full CIP capability.

Amberchrom HPR10 resin has been optimized to deliver high capacity for peptides, small proteins and other biomolecules. The unique combination of physical characteristics and structural rigidity enable AMBERCHROM HPR10 resin to provide improved selectivity and purity at operating pressures up to 100 bar. The high loading capabilities of the AMBERCHROM HPR10 resin enable economical, large scale operation for critical products such therapeutic peptides.

AMBERCHROM HPR10 resin's broad chemical compatibility allows you to use 1 N NaOH for CIP (clean in place) in your final polishing step, enabling full system CIP: capture, intermediate and polishing without degradation of performance. This stability also offers expanded operating ranges for separations of basic, polar or hydrophobic speciesproducts. Numerous examples of improved capacity, selectivity, and resolution have been demonstrated by shifting the pH from an acidic to a basic buffer system.

Moreover Amberchrom HPR10 resin extended lifetime contributes to reduce operating costs by eliminating the down time of in your plant to unpack, clean and repack silica media. The increased process throughput helps to drive down your overall chromatographic process costs.

AMBERCHROM HPR10 resin is available in bulk from analytical process development to industrial quantities and also as AMBERCHROM™ PROFILE™ reversed phase HPLC columns with a 4.6, 10, 20, 50 and 70 mm diameter for screening, process development and initial production for research purposes. For more information, please visit our internet site at www.amberchrom.com.
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Rohm and Haas Advanced Biosciences

185, rue de Bercy
75579 Paris Cedex 12

Phone: +33 1 40 02 54 01
Fax: +33 1 43 45 28 19