High Performance Single-Use Bioreactor

The CELL-tainer® is a novel wave-motion bioreactor characterized by very high mass-transfer capacities (KlA’s up to 200 h-1) due to an optimized wave motion. By comparison, this mass-transfer capacity is at least a factor 5 higher than that of stirred tank cell-culture bioreactors. As such, no oxygen supplementation of the overlay is required for oxygenation and the carbon dioxide stripping capacity is sufficient to prevent pCO2 build-up. Experiments with various cell lines showed that even higher cell densities, thus higher product titers are possible in the CELL-tainer®. The high mass transfer in the CELL-tainer® is sufficient to support oxygen consumption of high density cell cultures and certainly of most microbial applications.