Tools to Cover all GPCR Screening Applications

Upon activation, GPCRs carry information within the cell via two major signaling pathways: one results in variations of the cyclic AMP (cAMP) level whereas the other one results in the production of inositol phosphates. Cisbios IP-One assay, based on its proprietary HTRF technology, is the first system that can easily detect inositol(1)phosphate (IP1), which tightly correlates with Gq-coupled receptor activity. The new formulation of IP-One specially streamlined for HTS and uHTS requirements is now available (high Signal-to-Noise ratio and good Z factor).