In-Vivo Gene Delivery

BTX has introduced the ECM 830 square-wave electroporation system and specialty electrodes. Electroporation technology enhances cellular uptake of various molecules. Experimental cancer research now incorporates a direct injection of plasmid DNA into a tumor lesion, followed by electroporation. The localized electrical charge enhances the uptake of the plasmid DNA into tumor cells. The plasmid DNA then stimulates cells within the tumor to produce high levels of a specific protein which in turn stimulates the immune system to generate antibodies against the tumor cells. The BTX ECM 830 is specifically designed for mammalian cell and
electroporation. The 2-needle array electrodes are just one example of specialty electrodes used for
gene and drug delivery. Additional electrodes available include the Tweezertrode, Genetrode and Calliper electrodes.